Samarium-Mediated Asymmetric Synthesis

Samarium is an efficient reducing agent, a radical generator in cyclization and cascade addition reaction. Interestingly, samarium metal has crucial impact on numerous C-C C-X (X = hetero atom) bond forming transformations. It been established as exceptional chemo-selective stereoselective reagent. The reactivity of the catalyst/reagent remarkably enhanced presence various additives, ligands solvents through effective coordination increase reduction potential. inherent character to act electron donor for wide range transformations including asymmetric version reactions. This review accentuates developments samarium-mediated/catalyzed organic synthesis over past 12 years, where chirality induced from ligand, nearby center within substrate or directed stereospecific